Beyond Achondroplasia

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Role of FGF/FGFR signaling in skeletal development and homeostasis: learning from mouse models

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This article, published online today in Bone research journal, (Nan Su, Min Jin, lin Chen, Bone Research 2, Article number: 14003) is an enlightenment about the fibroblast growth factor and fibroblast growth factor receptor signaling.

In this review, that published quite exceptional figures and tables, the researchers “summarize the mouse models of FGF signaling-related skeleton diseases and recent progresses regarding the molecular mechanisms, underlying the role of FGFs/FGFRs in the regulation of bone development and homeostasis. Also provides a perspective view on future works to explore the roles of FGF signaling in skeletal development and homeostasis”.

Image

The regulation of osteogenesis by FGFR1-3. FGFRs play distinct roles during the differentiation of osteoblast. There are some conflicting results about the effect of FGFR3 on osteogenesis, which is marked by dotted lines. (image taken from the cited article)

 

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