The “Multicenter, Multinational Clinical Assessment Study for Pediatric Patients With Achondroplasia” is a prospective observational study. This study’s code name is 111-901.
The aim of this study is to collect systematic growth measurements of the children in order to collect data to better understand the natural history of achondroplasia.
Children between 2 and 13 years old can be enrolled in the 111-901 study. The measurements take place every 3 months and can go for up to 60 months (or 5 years).
BMN-111 will not be administered in this study. Yet, only children that participate in the study 111-901 can be enrolled in the drug study afterwards, with the code 111-301, in which BMN-111 will be administrated to 50% of participants while the others will receive a placebo.

Credits: Brakefield R. Observational Studies and Experiments, 2015
The 111-901 study is now being conducted at 21 clinical centers around the globe, and new centers have been added in the USA and centers in Spain and Turkey have been included. All centers are currently recruiting patients.
United States,
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Harbor-UCLA Medical Center | |
Los Angeles, California, United States, 90048 | |
Contact: Nathalia Patritti Cressey, Study Coord 310-781-3682 ext Office | |
Contact 310-597-1960 ext Cell | |
Principal Investigator: Patti Dickson, MD | |
Children’s Hospital and Research Center Oakland | |
Oakland, California, United States, 94609 | |
Contact: Jacqueline Madden, Study Coord 510-428-3885 ext 5745 | |
jmadden@mail.cho.org | |
Children’s Hospital Colorado | |
Aurora, Colorado, United States, 80045 | |
Contact: Laurel Ware, BSN 720-777-5378 | |
Principal Investigator: Gary Bellus | |
Nemours/Alfred I. duPont Hospital for Children | |
Wilmington, Delaware, United States, 19803 | |
Contact: Cassie Brown, Study Coord 302-298-7930 | |
Contact: Michael Bober, MD | |
Emory University | |
Decatur, Georgia, United States, 30033 | |
Contact: Elizabeth Smith, Study Coord | |
Contact: William Wilcox, MD | |
Ann and Robert H Lurie Children’s Hospital of Chicago | |
Chicago, Illinois, United States, 60614 | |
Contact: Victoria Sanders, Study Coord 312-227-6120 | |
Indiana University, Riley Children’s Hospital | |
Indianapolis, Indiana, United States, 46202 | |
Contact: Susan Romie 317-278-6650 | |
Principal Investigator: David Weaver, MD | |
Johns Hopkins McKusick- Institute of Genetic Medicine | |
Baltimore, Maryland, United States, 21287 | |
Contact: Adekemi Alade, Study Coord | |
Contact: Kira Lurman, Study Coord | |
University of Missouri | |
Columbia, Missouri, United States, 65201 | |
Contact: Vicki L Jones, Study Coord 573-882-7583 | |
Contact: Daniel G Hoernschemeyer, MD 573-882-1351 | |
Principal Investigator: Daniel G Hoernschemeyer, MD | |
Cincinnati Children’s Hospital Medical Center | |
Cincinnati, Ohio, United States, 45229 | |
Contact: Racheal Powers 800-647-4805 | |
Principal Investigator: Howard Saal, MD | |
Vanderbilt University | |
Nashville, Tennessee, United States, 37232 | |
Contact: LeeAnna Melton, Study Coord 615-343-6761 | |
Baylor College of Medicine | |
Houston, Texas, United States, 77030 | |
Contact: Catherine Loffredo, Study Coord | |
Seattle Children’s Hospital | |
Seattle, Washington, United States, 98105 | |
Contact: Tressa Mattioli-Lewis | |
Contact: Klane White, MD | |
Principal Investigator: Klane White, MD | |
Medical College of Wisconsin, Children’s Hospital | |
Milwaukee, Wisconsin, United States, 53226 | |
Contact: Paula Engelking 414-266-3289 | |
Contact: Donald Basel, MD | |
Principal Investigator: Donald Basel, MD
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Australia, Victoria | |
Murdoch Children’s Research Institute | |
Parkville, Victoria, Australia, 3052
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France | |
Institut Necker | |
Paris, France, 75015 | |
Contact: Kim-Hahn Le Quan Sang, MD 33 1 44 49 59 51 | |
Principal Investigator: Valerie Cormier-Daire, MD
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Spain | |
Institut Catala de Traumatologica I Medicina de l’Esport | |
Barcelona, Spain, 08028 | |
Contact: Miriam Perez +34 932 05 43 62 ext 21148 | |
Contact: Ignacio Ginebreda +34 619 21 35 77 | |
Principal Investigator: Ignacio Ginebreda | |
Hospital Sant Joan de Deu Barcelona | |
Barcelona, Spain, 08950 | |
Contact: Jose Maria de Bergua +34 650 80 60 71 | |
Contact: Rosendo Ullot +34 650 80 60 71 | |
Principal Investigator: Rosendo Ullot | |
Hospital Universitario Virgen de la Victoria | |
Málaga, Spain, 29010 | |
Contact: Antonio Leiva +34 646 56 87 89 | |
Contact: Felipe Luna +34 607 85 81 22 | |
Principal Investigator: Felipe Luna
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Turkey | |
Acibadem University School of Medicine | |
Istanbul, Turkey, 34752 | |
Contact: Beyzanur Gonenc +90 532 300 09 13 | |
Contact: Burcu Menderes +90 555 313 40 86 | |
Principal Investigator: Yesemin Alanay, MD | |
Sub-Investigator: Selda Karaayvaz
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United Kingdom | |
Guy’s and St. Thomas NHS Foundation Trust Evelina Children’s Hospital | |
London, United Kingdom, SE1 9RT | |
Principal Investigator: Melita Irving, MD |
Information available on Clinicaltrials.gov
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