The “Multicenter, Multinational Clinical Assessment Study for Pediatric Patients With Achondroplasia” is a prospective observational study. This study’s code name is 111-901.

The aim of this study is to collect systematic growth measurements of the children in order to collect data to better understand the natural history of achondroplasia.

Children between 2 and 13 years old can be enrolled in the 111-901 study. The measurements take place every 3 months and can go for up to 60 months (or 5 years).

BMN-111 will not be administered in this study. Yet, only children that participate in the study 111-901 can be enrolled in the drug study afterwards, with the code 111-301, in which BMN-111 will be administrated to 50% of participants while the others will receive a placebo.

The 111-901 study is now being conducted at 21 clinical centers around the globe, and new centers have been added in the USA and centers in Spain and Turkey have been included. All centers are currently recruiting patients.

United States,
Harbor-UCLA Medical Center
Los Angeles, California, United States, 90048
Contact: Nathalia Patritti Cressey, Study Coord    310-781-3682 ext Office
Contact    310-597-1960 ext Cell
Principal Investigator: Patti Dickson, MD
Children’s Hospital and Research Center Oakland
Oakland, California, United States, 94609
Contact: Jacqueline Madden, Study Coord    510-428-3885 ext 5745
jmadden@mail.cho.org
Children’s Hospital Colorado
Aurora, Colorado, United States, 80045
Contact: Laurel Ware, BSN    720-777-5378 laurel.ware@childrenscolorado.org
Principal Investigator: Gary Bellus
Nemours/Alfred I. duPont Hospital for Children
Wilmington, Delaware, United States, 19803
Contact: Cassie Brown, Study Coord    302-298-7930 cassondra.brown@nemours.org
Contact: Michael Bober, MD
Emory University
Decatur, Georgia, United States, 30033
Contact: Elizabeth Smith, Study Coord Elizabeth.d.smith@emory.edu
Contact: William Wilcox, MD William.wilcox@emory.edu
Ann and Robert H Lurie Children’s Hospital of Chicago
Chicago, Illinois, United States, 60614
Contact: Victoria Sanders, Study Coord    312-227-6120
Indiana University, Riley Children’s Hospital
Indianapolis, Indiana, United States, 46202
Contact: Susan Romie    317-278-6650 sromie@iu.edu
Principal Investigator: David Weaver, MD
Johns Hopkins McKusick- Institute of Genetic Medicine
Baltimore, Maryland, United States, 21287
Contact: Adekemi Alade, Study Coord aalade2@jhmi.edu
Contact: Kira Lurman, Study Coord Kmarant1@jhmi.edu
University of Missouri
Columbia, Missouri, United States, 65201
Contact: Vicki L Jones, Study Coord    573-882-7583 umhsorthoenroll@health.missouri.edu
Contact: Daniel G Hoernschemeyer, MD    573-882-1351
Principal Investigator: Daniel G Hoernschemeyer, MD
Cincinnati Children’s Hospital Medical Center
Cincinnati, Ohio, United States, 45229
Contact: Racheal Powers    800-647-4805
Principal Investigator: Howard Saal, MD
Vanderbilt University
Nashville, Tennessee, United States, 37232
Contact: LeeAnna Melton, Study Coord    615-343-6761 leeanna.melton@vanderbilt.edu
Baylor College of Medicine
Houston, Texas, United States, 77030
Contact: Catherine Loffredo, Study Coord catherine.loffredo@bcm.edu
Seattle Children’s Hospital
Seattle, Washington, United States, 98105
Contact: Tressa Mattioli-Lewis tressa.mattiolilewis@seattlechildrens.org
Contact: Klane White, MD klane.white@seattlechildrens.org
Principal Investigator: Klane White, MD
Medical College of Wisconsin, Children’s Hospital
Milwaukee, Wisconsin, United States, 53226
Contact: Paula Engelking    414-266-3289 pengelki@mcw.edu
Contact: Donald Basel, MD dbasel@mcw.edu
Principal Investigator: Donald Basel, MD
Australia, Victoria
Murdoch Children’s Research Institute
Parkville, Victoria, Australia, 3052
France
Institut Necker
Paris, France, 75015
Contact: Kim-Hahn Le Quan Sang, MD    33 1 44 49 59 51 kh.lequansang@nck.aphp.fr
Principal Investigator: Valerie Cormier-Daire, MD
Spain
Institut Catala de Traumatologica I Medicina de l’Esport
Barcelona, Spain, 08028
Contact: Miriam Perez    +34 932 05 43 62 ext 21148 miriam.perez@icatme.com
Contact: Ignacio Ginebreda    +34 619 21 35 77 ignacio.ginebreda@icatme.com
Principal Investigator: Ignacio Ginebreda
Hospital Sant Joan de Deu Barcelona
Barcelona, Spain, 08950
Contact: Jose Maria de Bergua    +34 650 80 60 71
Contact: Rosendo Ullot    +34 650 80 60 71 rullot@hsjdbcn.org
Principal Investigator: Rosendo Ullot
Hospital Universitario Virgen de la Victoria
Málaga, Spain, 29010
Contact: Antonio Leiva    +34 646 56 87 89
Contact: Felipe Luna    +34 607 85 81 22
Principal Investigator: Felipe Luna
Turkey
Acibadem University School of Medicine
Istanbul, Turkey, 34752
Contact: Beyzanur Gonenc    +90 532 300 09 13 beyzanur.gonenc@acibadem.edu.tr
Contact: Burcu Menderes    +90 555 313 40 86 burcu.menderes@acibadem.edu.tr
Principal Investigator: Yesemin Alanay, MD
Sub-Investigator: Selda Karaayvaz
United Kingdom
Guy’s and St. Thomas NHS Foundation Trust Evelina Children’s Hospital
London, United Kingdom, SE1 9RT
Principal Investigator: Melita Irving, MD

Information available on Clinicaltrials.gov