Beyond Achondroplasia

Growing together with Clara

A new device for treatment of persistent otitis media with effusion

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Dr. Armin Bidarian Moniri, a swedish ENT doctor working in Portugal, developed a device that helps children of a younger age to balance the pressure and aerating the middle ear. The principles applied in this device toy are the Valsalva maneuver and the Politzer Maneuver, that younger children can´t do by themselves.

The Valsalva maneuver is performed by moderately forceful attempted exhalation against a closed airway, usually done by closing the mouth, pinching the nose shut while pressing out as if blowing up a balloon. It can be used either to “clear” the ears and sinuses (that is, to equalize pressure between them)

The technique is named after Antonio Maria Valsalva a 17th-century physician and anatomist from Bologna whose principal scientific interest was the human ear. He described the Eustachian tube and the maneuver to test its patency (openness). He also described the use of this maneuver to expel pus from the middle ear.

The Politzer maneuver is a medical procedure that involves inflating the middle ear by blowing air up the nose during the act of  swallowing. It is often performed to reopen the Eustachian tube and equalise pressure in the sinuses.

Four centuries after, Dr. Moniri developed this device, that will be marketed soon with the trade name of Moniri-Otovent. This can be a new approach to substantially reduce the episodes of otitis media in children with achondroplasia.

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In the abstract of the article published in the International Journal of Pediatric Otorhinolaryngology – 2013:

“Most children suffer from otitis media with effusion (OME) before starting school. Insertion of grommets into the eardrum for treatment of OME is one of the most common operations performed in childhood. The efficiency and compliance of treatment with a new non-invasive device was evaluated in children with bilateral OME with disease duration of at least 3 months”

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One Comment

  1. Hi Clara’s Mom,
    Another therapy to treat achondroplasia is PTH,

    The major negatives effects (Apoptosis and cessation of proliferation) of FGFR3 on chondrocytes is caused by down regulation of PTHrp,

    here = http://tratando-acondroplasia.blogspot.com.br/2012/07/parathyroid-hormone-to-treat.html

    Application of PTH on achondroplasia:

    Achondroplasia and TD ACH partially rescued in mice by PTH =

    http://hmg.oxfordjournals.org/content/21/18/3941.full

    PTH Fully recovery growth of Fetal long bones to normal lengths =
    http://www.acondroplasiauruguay.org/documentos/informacion%20medica/b/2/PTH%20potencial%20cura%20de%20Acondroplasia.pdf
    http://www.ncbi.nlm.nih.gov/pubmed/17466614
    http://www.sciencedirect.com/science/article/pii/S8756328207000609
    http://www.ncbi.nlm.nih.gov/pubmed/15775247
    http://www.irdrjournal.com/action/downloaddoc.php?docid=671
    http://www.crecimiento.org/biblio/novel.pdf
    http://www.ncbi.nlm.nih.gov/pubmed/12929929

    PTH is available to the public in the form of analogue used to treat osteoporosis,

    Teriparatide is the name,

    it has been studied in many cartilage related diseases,

    http://stm.sciencemag.org/content/3/101/101ra93/reply

    I would not recommend you guys utilize growth hormone,
    because the GH only increases the growth rate in the first year in childrens with ACH, in the second year the growth rate down to poor values

    See for yourself:

    https://www.google.com.br/search?q=Growth+hormone+achondroplasia+site%3Awww.ncbi.nlm.nih.gov&oq=Growth+hormone+achondroplasia+site%3Awww.ncbi.nlm.nih.gov&aqs=chrome..69i57.55942j0&sourceid=chrome&ie=UTF-8

    IGF-1 (Mecasermin) but is very promising, significantly increases the growth rate and adult height in people with Laron-type dwarfism:

    The increase in Final adult height is more than 30 cms:

    http://press.endocrine.org/doi/pdf/10.1210/jcem.86.4.7381
    http://press.endocrine.org/doi/pdf/10.1210/jc.2006-1610
    http://www.ncbi.nlm.nih.gov/pubmed/10619985
    http://www.ncbi.nlm.nih.gov/pubmed/8808010
    http://www.ncbi.nlm.nih.gov/pubmed/8334752

    Good lucky Clara,

    (I talked to Kinji Ohno (the head of the research team meclozine) and he told me that so far meclozine is giving the expected results in rats,)
    I’m here to help

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